Beckmann Lab

With my independent junior research group we work in the field of molecular infection biology to understand the interaction of pathogenic bacteria and their host cells. The research focus is on RNA-protein interactions during infection. In particular, we want to identify and characterize bacterial non-coding RNAs and RNA-binding proteins (RBPs) that modify post-transcriptional regulation of gene expression of the host cell and thus contribute to the pathogenicity of the pathogen.

Applying state-of-the-art systems biology approaches such as mRNA interactome capture, we analyze how infection with e.g. Salmonella Typhimurium impacts (m)RNP composition in macrophages of human and mouse hosts as well as search for bacterial RBPs forming cross-species RNA-protein interactions.